In this free webinar, gain insights into increasing the downstream processing and purification of cell and gene therapeutics. Attendees will learn about amplifying downstream processing efficiency of nucleic acid targets and lentiviral vectors with next-generation nanofiber technology. The featured speakers will share insights into developing strategies to address the rapidly expanding pipeline of complex and diverse modalities. Attendees will also learn about achieving intensified productivity through an integrated approach that combines disruptive technologies with existing single-use infrastructures.
TORONTO, Jan. 30, 2025 /PRNewswire-PRWeb/ -- Join this webinar to learn how target-specific adsorbents enable increase in productivity due to increased manufacturing speed and recovery yield while achieving the purity levels for the product quality attributes required by regulatory authorities.
A novel purification approach is required to address the complex purification challenges of critical raw materials for cell and gene therapies (CGT) such as plasmid DNA (pDNA) and lentiviral vectors (LVV). The purification technology needs to be optimized for large and fragile CGT modalities, allowing downstream processing under low operational pressure and low salt buffers.
In this webinar, the expert speakers will share data and insights on the development of a low salt, high recovery yield and lentiviral vector purification workflow, with efficient removal of impurities such as host cell proteins and dsDNA. Attendees will also learn how the performance of the anion exchange adsorbent compares to alternative commercially available chromatography options. The expert speakers will also discuss a scalable downstream workflow for efficient pDNA manufacturing at full-speed operation while maintaining low column pressure.
Attendees will also learn how processing of highly viscous feeds such as large pDNA sequences (e.g., greater than 10 kb) required in CGT can be considerably simplified. The speaker will also demonstrate how the hydrophobic adsorbent integrated into the flexible workflow can be used as a capture step or a polish step to adapt to the varying and growing process needs.
Register for this webinar today to gain insights into increasing the downstream processing and purification of cell and gene therapeutics.
Join experts from Astrea Bioseparations, Ian Scanlon, Nanofiber Development Lead; and Dr. Christie Childers, Senior Scientist, Downstream Processing, for the live webinar on Thursday, February 20, 2025, at 9:30am EST (3:30pm CET/EU-Central).
For more information, or to register for this event, visit Success Stories for Challenging pDNA and Viral Vectors Downstream Processing.
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